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73573-88-3 - Mevastatin, 98% - J61357 - Alfa Aesar

J61357 Mevastatin, 98%

CAS-Nummer
73573-88-3
Synonyme

Größe Preis ($) Menge Verfügbarkeit
5mg 41,20
10mg 71,30
25mg 99,10
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

Mevastatin, 98%

MDL
MFCD05662341

Chemische Eigenschaften

Formel
C23H34O5
Molmasse
390.52
Form
Crystalline solid
Löslichkeit
Soluble in ethanol at 25 mg/mL and in DMSO at 20mg/ml

Anwendungen

Mevastatin (Compactin) inhibits HMGCR (HMG-CoA reductase) , induces apoptosis which in turn inhibits isoprenoid biosynthesis and therefore blocks protein isoprenylation and reduces plasma cholesterol levels in humans. Mevastatin causes cells to arrest early in the G1 phase. Mevastatin is a close structural analog of lovastatin and both agents have the same biochemical and pharmacological activities. Mevastatin is inactive in cell-free assays. In cells however, it is hydrolyzed to the active free acid form by intracellular esterases.

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C

Literaturverweise

C M Shipman et. al. The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway. Cancer Research. 1998, 58, (23), 5294-5297.

U Laufs and J K Liao. Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase. Journal of Biological Chemistry. 1998, 273, (37), 24266-24271.

Weitere Referenzen

Merck
14,6164
Beilstein
1269441
Harmonized Tariff Code
2932.20
TSCA
No
RTECS
EK7907100

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