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Telmisartan also acts as a partial agonist of PPARγ, activating the receptor to 25-30% of that produced by the full agonist rosiglitazone (EC50 = 4.5 ?M). Through these actions, telmisartan potently reduces blood pressure in various animal models of hypertension, diminishing cardiac hypertrophy, cardiovascular and renal risk, and glomerulosclerosis.
B Martina.; T Dieterle.; JP Sigle.; C Surber.; E Battegay. Effects of telmisartan and losartan on left ventricular mass in mild-to-moderate hypertension. Cardiology. 2003, 99, (3), 169-170.
AR Zankl.; B Ivandic.; M Andrassy.; HC Volz. Telmisartan improves absolute walking distance and endothelial function in patients with peripheral artery disease. Clinical Research in Cardiology. 2010, 99, (12), 787-794.