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144701-48-4 - Telmisartan, 99% - BIBR 277 - 4'-[(1,4'-Dimethyl-2'-n-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]biphenyl-2-carboxylic acid - J61441 - Alfa Aesar

J61441 Telmisartan, 99%

CAS-Nummer
144701-48-4
Synonyme
BIBR 277
4'-[(1,4'-Dimethyl-2'-n-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]biphenyl-2-carboxylic acid

Größe Preis ($) Menge Verfügbarkeit
250mg 54,59
1g 163,77
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

Telmisartan, 99%

MDL
MFCD00918125

Chemische Eigenschaften

Formel
C33H30N4O2
Molmasse
514.62
Form
Powder
Schmelzpunkt
261-263°
Löslichkeit
Soluble in DMSO (13 mg/ml at 25°C), chloroform, DMF (~1.6 mg/ml), and ethanol (<1 mg/ml at 25°C). Insoluble in water.

Anwendungen

Telmisartan also acts as a partial agonist of PPAR&#947;, activating the receptor to 25-30% of that produced by the full agonist rosiglitazone (EC50 = 4.5 ?M). Through these actions, telmisartan potently reduces blood pressure in various animal models of hypertension, diminishing cardiac hypertrophy, cardiovascular and renal risk, and glomerulosclerosis.

Bemerkungen

Hygroscopic, -20°C Freezer, Under Inert Atmosphere. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Literaturverweise

B Martina.; T Dieterle.; JP Sigle.; C Surber.; E Battegay. Effects of telmisartan and losartan on left ventricular mass in mild-to-moderate hypertension. Cardiology. 2003, 99, (3), 169-170.

AR Zankl.; B Ivandic.; M Andrassy.; HC Volz. Telmisartan improves absolute walking distance and endothelial function in patients with peripheral artery disease. Clinical Research in Cardiology. 2010, 99, (12), 787-794.

Weitere Referenzen

Merck
14,9129
Harmonized Tariff Code
2933.99
TSCA
No
RTECS
DV2037500

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