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L-Histidine is used in cell culture media formulations used in biomanufacturing. L-Histidine has been used to study cultures of the human T-lymphoblastic leukemia cell line MOLT-4 to study modulation of apoptosis.
Thomas Osterberg.; Tommy Wadsten. Physical state of l-histidine after freeze-drying and long-term storage. European Journal of Pharmaceutical Sciences. 1999, 8, (4), 301-308.