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4449-51-8 - Cyclopamine, 99% - 11-Deoxyjervine - J61528 - Alfa Aesar

J61528 Cyclopamine, 99%

CAS-Nummer
4449-51-8
Synonyme
11-Deoxyjervine

Größe Preis ($) Menge Verfügbarkeit
25mg 234,00
50mg 474,83
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Cyclopamine, 99%

MDL
MFCD01735266

Chemische Eigenschaften

Formel
C27H41NO2
Molmasse
411.62
Form
Powder
Schmelzpunkt
234-237°
Löslichkeit
Soluble in ethanol (5 mg/ml warm), DMSO (4 mg/ml), DMF (10 mg/ml), methylene chloride, chloroform, methanol (7 mg/ml), and benzene.

Anwendungen

Cyclopamine, is used as a hedgehog [Hh] signaling pathway and Smo inhibitor. It depletes stem-like cancer cells in glioblastoma and blocks tumor engraftment. Can also be used to induce differentiation of human embryonic stem cells (hESCs) into hormone-expressing endocrine cells.

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C. Keep away from strong oxidizing agents.

Literaturverweise

Chen et al. Inhibition of hedgehog signaling by direct binding of cyclopamine to smoothened. Genes Dev. 2002, 16, (21), 2743-8.

D'Amour et al. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat.Biotechnol. 2006, 24, (11), 1392-401.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H341-H361

Suspected of causing genetic defects. Suspected of damaging fertility or the unborn child.

Sicherheitshinweise: P201-P281-P202-P308+P313-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Do not handle until all safety precautions have been read and understood. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Harmonized Tariff Code
2932.99
TSCA
No
RTECS
GY0750000

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