Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

129-46-4 - Suramin hexasodium salt, 98+% - J61707 - Alfa Aesar

J61707 Suramin hexasodium salt, 98+%

CAS-Nummer
129-46-4
Synonyme

Größe Preis ($) Menge Verfügbarkeit
250mg 207,00
500mg 274,00
1g 517,00
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

Suramin hexasodium salt, 98+%

MDL
MFCD00210217
EINECS
204-949-3

Chemische Eigenschaften

Formel
C51H34N6Na6O23S6
Molmasse
1429.16
Form
Powder
Löslichkeit
Soluble in water and saline. Sparingly soluble in 95% bethanol

Anwendungen

Suramin Sodium has been observed as a potent inhibitor of melanoma HPA (heparanase) and tumor cell metastasis. Inhibition of NAD+-dependent deacetylase SIRT1 with an IC50 of 2.6 ?M along with SIRT5 has also been observed. Suramin Sodium has been recorded to antagonize EDG-3 (S1P3) selectively. Suramin Sodium is an inhibitor of A cyclase, FGF-1, FGF-2, IL-1, IL-4, PDGF, PC-PLD, PKC, SH-PTP, TERT, TGF beta 1, Topo I, Topo II and VEGF. It is used as a G protein uncoupler and inhibitor of PDGF, EGF, TGF-β, SIRT1 and SIRT5. It also blocks calmodulin binding to recognition sites and G protein coupling to G protein-coupled receptors. Increases open probability of ryanodine receptor (RyR) channels. Anticancer and antiviral agent.

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Literaturverweise

Voogd et al. Recent research on the biological activity of suramin. Pharmacol.Rev. < span>1993, 45, (2), 177-203.

Beindl et al. Inhibition of receptor/G protein coupling by suramin analogues. Mol.Pharmacol. < span>1996, 50, (2), 415-23.

Weitere Referenzen

Merck
14,9006
Beilstein
3694087
Harmonized Tariff Code
2924.29
TSCA
No
RTECS
QM7000000

Empfohlen

  • 36636

    2-Chloroethanol, 99%
  • B21597

    6-Chloro-4-hydroxy-2-(trifluoromethyl)quinoline, 97+%
  • 12557

    Palladium rod, 6.35mm (0.25in) dia, 99.95% (metals basis)
  • A14315

    Polyvinylpyrrolidone, average M.W. 58,000
  • H66264

    5-(Fmoc-amino)valeric acid, 98%

Kürzlich angesehen

Chemikalien

Life science

Metalle und Stoffe

Katalysatoren

Forschungs- und Laborbedarf