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51-45-6 - Histamine - J61727 - Alfa Aesar

J61727 Histamine

CAS-Nummer
51-45-6
Synonyme

Histamine

MDL
MFCD00005210
EINECS
200-100-6

Chemische Eigenschaften

Formel
C5H9N3
Molmasse
111.15
Form
Powder
Löslichkeit
Soluble in water, alcohol, and hot chloroform.

Anwendungen

Histamine inhibits the synthesis of IL-2 and γ-IFN in peripheral blood mononuclear cells and lipopolysaccharide-induced synthesis of TNF-α in monocytes via H2 receptor activation. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C Hygroscopic. Handle and store under inert gas. Air sensitive.

Literaturverweise

PA Shore.; A Burkhalter.; VH Cohn. A method for the fluorometric assay of histamine in tissues. JPET. < span>1959, 127, (3), 182-186.

JM Arrang.; M Garbarg.; JC Schwartz. Auto-inhibition of brain histamine release mediated by a novel class (H3) of histaminereceptor. Nature. < span>1983, 302, (3), 832 - 837.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H301-H315-H319-H317-H335-H334

Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause an allergic skin reaction. May cause respiratory irritation. May cause allergy or asthma symptoms or breathing difficulties if inhaled.

Sicherheitshinweise: P285-P261-P280-P301+P310-P305+P351+P338-P304+P340-P342+P311-P362-P405-P501a

In case of inadequate ventilation wear respiratory protection. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. Take off contaminated clothing and wash before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,4719
Beilstein
2012
Gefahrenklasse
6.1
Verpackungsgruppe
III
Harmonized Tariff Code
2933.29
TSCA
Yes
RTECS
MS1050000

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