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38194-50-2 - Sulindac - cis-5-Fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]indene-3-acetic acid - MK-231 - J61772 - Alfa Aesar

J61772 Sulindac

CAS-Nummer
38194-50-2
Synonyme
cis-5-Fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]indene-3-acetic acid
MK-231

Größe Preis ($) Menge Verfügbarkeit
5g 55,62
25g 222,48
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Sulindac

MDL
MFCD00599589
EINECS
253-819-2

Chemische Eigenschaften

Formel
C20H17FO3S
Molmasse
356.41
Form
Powder
Schmelzpunkt
182-185°
Löslichkeit
Soluble in water, methanol, ethanol.

Anwendungen

Sulindac inhibits the NF-κB pathway. Sulindac is a non-steroidal anti-inflammatory drug. Sulindac reduces the level and activity of several cyclin-dependent kinases and induces apoptosis. It is an antitumor agent. Sulindac is an inhibitor of Cox-1 and Cox-2.

Bemerkungen

Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literaturverweise

William R. Waddell.; Gary F. Ganser.; Elmo J. Cerise.; Richard W. Loughry. Sulindac for polyposis of the colon. The American Journal of Surgery. 1989, 157, (1), 175-179.

William R. Waddell.; Richard W. Loughry. Sulindac for polyposis of the colon. Journal of Surgical Oncology. 1983, 24, (1), 83-87.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H301-H317-H334-H361

Toxic if swallowed. May cause an allergic skin reaction. May cause allergy or asthma symptoms or breathing difficulties if inhaled. Suspected of damaging fertility or the unborn child.

Sicherheitshinweise: P285-P201-P261-P280-P281-P301+P310-P342+P311-P363-P405-P501a

In case of inadequate ventilation wear respiratory protection. Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Use personal protective equipment as required. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,8982
Gefahrenklasse
6.1
Verpackungsgruppe
III
Harmonized Tariff Code
2930.90
TSCA
No
RTECS
NK8226000

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