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56-25-7 - Cantharidin, 98% - J61801 - Alfa Aesar

J61801 Cantharidin, 98%

CAS-Nummer
56-25-7
Synonyme

Größe Preis ($) Menge Verfügbarkeit
100mg 183,00
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Cantharidin, 98%

MDL
MFCD00134968
EINECS
200-263-3

Chemische Eigenschaften

Formel
C10H12O4
Molmasse
196.20
Form
Powder
Schmelzpunkt
215-217°
Löslichkeit
Soluble in DMSO (25 mg/ml warm), acetone (8 mg/ml), ethanol (8 mg/ml warm), chloroform (1:65), ether (1:560), and ethyl acetate (1:150).

Anwendungen

Cantharidin is used as a potent inhibitor of PP2A phosphatase activity. It has been shown to stimulate cell cycle progression and induce premature mitosis, used topically (0.7%) as an anti-wart treatment, and has been shown to be active in cervical, tongue, neuroblastoma, bone, leukemia, ovarian, colon, and various other cancer cell lines.

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents.

Literaturverweise

T I Baskin; J E Wilson. Inhibitors of protein kinases and phosphatases alter root morphology and disorganize cortical microtubules. Plant Physiology.1997, 113 , (2), 493-502.

McCluskey A.; Sim A.T.R.; and Sakoff J.A. Serine-threonine protein phosphatase inhibitors: Development of potential therapeutic strategies. J Med Chem.2002, 45 , (6), 1151-1175.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H300-H315-H319-H335

Fatal if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Sicherheitshinweise: P261-P280a-P301+P310a-P305+P351+P338-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,1752
Gefahrenklasse
6.1
Verpackungsgruppe
I
Harmonized Tariff Code
2918.99
TSCA
Yes
RTECS
RN8575000

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