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Metoprolol tartrate is an antagonist of the β1-AR (β1-adrenoceptor). It inhibits spontaneous endothelin-1 production in vitro and displays antihypertensive and antianginal activity in vivo.
Jef Stappaerts; Benjamin Wuyts; Jan Tack; Pieter Annaert; Patrick Augustijns. Human and simulated intestinal fluids as solvent systems to explore food effects on intestinal solubility and permeability. European Journal of Pharmaceutical Sciences. 2012, 63,
Moran Zur; Allison S. Hanson; Arik Dahan. The complexity of intestinal permeability: Assigning the correct BCS classification through careful data interpretation. European Journal of Pharmaceutical Sciences. 2014, 61, 11-17.