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305-03-3 - Chlorambucil, 98% - 4-(4-[Bis(2-chloroethyl)amino]phenyl)butyric acid - J61964 - Alfa Aesar

J61964 Chlorambucil, 98%

CAS-Nummer
305-03-3
Synonyme
4-(4-[Bis(2-chloroethyl)amino]phenyl)butyric acid

Größe Preis ($) Menge Verfügbarkeit
500mg 40,70
1g 68,80
5g 324,00
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Chlorambucil, 98%

MDL
MFCD00021783
EINECS
206-162-0

Chemische Eigenschaften

Formel
C14H19Cl2NO2
Molmasse
304.21
Form
Powder
Schmelzpunkt
66-67°
Löslichkeit
Soluble in ether, and ethanol:chloroform:acetone (3:5:4) (warm). Insoluble in water.

Anwendungen

Chlorambucil is an anti-cancer drug that alkylates DNA and induces apoptosis. It can be covalently coupled to monoclonal anticarcinombryonic antigen.

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C. Keep away from strong oxidizing agents.

Literaturverweise

 Soler M.; González-Bártulos M.; Figueras E.; Ribas X.; Costas M.; Massaguer A.; Planas M.;Feliu L. Enzyme-triggered delivery of chlorambucil from conjugates based on the cell-penetrating peptide BP16. Org Biomol Chem. 2015, 13, (5), 1470-80.

Wang X.; Li J.; Xu C.; Li Y.; Gong T.; Sun X.; Fu Y.; He Q.; Zhang Z. Scopine as a novel brain-targeting moiety enhances the brain uptake of chlorambucil. Bioconjug Chem. 2014, 25, (11), 2046-54.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H301-H315-H319-H335-H350

Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. May cause cancer.

Sicherheitshinweise: P201-P261-P280-P281-P301+P310-P305+P351+P338-P304+P340-P362-P405-P501a

Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Use personal protective equipment as required. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,2073
Beilstein
999011
Gefahrenklasse
6.1
Verpackungsgruppe
III
Harmonized Tariff Code
2922.49
TSCA
No
RTECS
ES7525000

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