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93479-97-1 - Glimepiride - J62032 - Alfa Aesar

J62032 Glimepiride

CAS-Nummer
93479-97-1
Synonyme

Größe Preis ($) Menge Verfügbarkeit
100mg 124,00
1g 345,05
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Glimepiride

MDL
MFCD00878417

Chemische Eigenschaften

Formel
C24H34N4O5S
Molmasse
490.62
Form
Powder
Schmelzpunkt
212-215°
Löslichkeit
Soluble in DMSO

Anwendungen

Glimepiride induces the PI3 kinase (PI3K) and Akt pathway, along with insulin receptor substrate-1/2 and endothelial nitric oxide synthase. Glimepiride also increases osteoblast proliferation and differentiation, which is thought to be related to its ability to activate the PI3K and Akt pathway. Furthermore, Glimepiride enhances intrinsic peroxisome proliferator-activated receptor γ activity. Glimepiride also increases protein expression of glucose transports 1 and 4, and is a potent KIR channel blocker. Potent Kir6 (KATP) channel blocker and anti-diabetic agent. Inhibits pinacidil-activated cardiac Kir6 channels with an IC50 of 6.8 nM.

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Literaturverweise

Lawrence et al. Effect of metabolic inhibition on glimepiride block of native and cloned cardiac sacrolemmal KATP channels. Br.J.Pharmacol. 2002, 136, (5), 746-52.

SE Nissen.; SJ Nicholls.; K Wolski.; R Nesto.; S Kupfer. Comparison of pioglitazone vs glimepiride on progression of coronary atherosclerosis in patients with type 2 diabetes: the periscope randomized controlled . JAMA. 2008, 299, (13), 1561-1573.

Weitere Referenzen

Merck
14,4440
Harmonized Tariff Code
2935.00
TSCA
No
RTECS
UX9363950

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