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It induces cell differentiation and apoptosis of some cancer cell types and inhibiting carcinogenesis. It plays an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. It acts as a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR) that act as transcription factors to regulate the growth and differentiation of normal and malignant cells.
Arora A.; Willhite CA.; Liebler DC. Interactions of beta-carotene and cigarette smoke in human bronchial epithelial cells. Carcinogenesis. 2001, 22, (8), 1173-1178.
French AL.; Kirstein LM.; Massad LS.; et al. Association of vitamin A deficiency with cervical squamous intraepithelial lesions in human immunodeficiency virus-infected women. J Infect Dis. 2000, 182, (4), 1084-1089.
Gefahrenhinweise (EU): H302-H319-H317-H360
Harmful if swallowed. Causes serious eye irritation. May cause an allergic skin reaction. May damage fertility or the unborn child.
Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.