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32004-67-4 - Sulindac sulfide - J62104 - Alfa Aesar

J62104 Sulindac sulfide

CAS-Nummer
32004-67-4
Synonyme

Größe Preis ($) Menge Verfügbarkeit
100mg 247,20
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Sulindac sulfide

MDL
MFCD00869764
EINECS
250-892-2

Chemische Eigenschaften

Formel
C20H17FO2S
Molmasse
340.41
Form
Powder
Schmelzpunkt
189-191°
Löslichkeit
Soluble in DMSO

Anwendungen

It is also shown to inhibit growth and induce apoptosis in human prostate cancer cells through a COX-1 and COX-2 independent mechanism. Sulindac sulfide is an analgesic that has antiproliferative and apoptotic effects. It inhibits the expression and activity of cyclooxygenase-2 in human colon cancer cells, and reduces tumor burden in adenomatous polyposis patients. Human endothelial cells, HMEC-1 were treated with Sulindac sulfide and the effect on cell survival was studies by MTT assay.

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Literaturverweise

S Flis et. al. Antiangiogenic effect of sulindac sulfide could be secondary to induction of apoptosis and cell cycle arrest. Anticancer Research. 2006, 26, ( 4B), 3033-3041.

M T Taylor et. al. Sulindac sulfone inhibits K-ras-dependent cyclooxygenase-2 expression in human colon cancer cells. Cancer Research. 2000, 60, ( 23), 6607-6610.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H334-H317-H361-H302

May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction. Suspected of damaging fertility or the unborn child. Harmful if swallowed.

Sicherheitshinweise: P285-P201-P261-P280-P281-P342+P311-P301+P312-P363-P405-P501a

In case of inadequate ventilation wear respiratory protection. Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Use personal protective equipment as required. If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Harmonized Tariff Code
2930.90
TSCA
No
RTECS
NK8236000

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