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111470-99-6 - Amlodipine besylate, 98+% - J62164 - Alfa Aesar

J62164 Amlodipine besylate, 98+%

CAS-Nummer
111470-99-6
Synonyme

Größe Preis ($) Menge Verfügbarkeit
1g 102,18
5g 376,98
25g 392,00
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Amlodipine besylate, 98+%

MDL
MFCD00887594

Chemische Eigenschaften

Formel
C20H25ClN2O5.C6H5SO3H
Molmasse
567.05
Form
Solid
Schmelzpunkt
195-204°
Löslichkeit
Soluble in DMSO (?20 mg/mL), water (10 mM), chloroform, ethanol (?14 mg/mL), and methanol.

Anwendungen

Amlodipine besylate is used as a dihydropyridine calcium channel blocker. It is also used as an antianginal and antihypertensive. Amlodipine besylate also displays vasoprotective effects in cardiovascular disease and inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM). Amlodipine besylate has been shown to inhibit proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells.

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Literaturverweise

Burges et al. Calcium channel blocking properties of amlodipine in vascular smooth muscle and cardiac muscle in vitro: evidence for voltage modulation of vascular dihydropyridine receptors. J.Cardiovasc.Pharmacol. 1987, 9, ( 1), 110-9.

Yoshida et al. Antiproliferative effect of Ca2+ channel blockers on human epidermoid carcinoma A431 cells. Eur.J.Pharmacol. 2003, 472, ( 1-2), 23-31.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Sicherheitshinweise: P261-P280-P305+P351+P338-P304+P340-P362-P301+P312-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,491
Harmonized Tariff Code
2933.39
TSCA
No
RTECS
US7967700

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