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17440-83-4 - Amiloride hydrochloride dihydrate - N-Amidino-3,5-diamino-6-chloropyrazine-2-carboxamide hydrochloride - J62168 - Alfa Aesar

J62168 Amiloride hydrochloride dihydrate

CAS-Nummer
17440-83-4
Synonyme
N-Amidino-3,5-diamino-6-chloropyrazine-2-carboxamide hydrochloride

Größe Preis ($) Menge Verfügbarkeit
1g 42,00
5g 162,00
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Amiloride hydrochloride dihydrate

MDL
MFCD00058197
EINECS
217-958-2

Chemische Eigenschaften

Formel
C6H8ClN7O.HCl•2H2O
Molmasse
266.09
Form
Powder
Schmelzpunkt
>240°
Löslichkeit
Soluble in water at 50mg/ml

Anwendungen

Amiloride hydrochloride dihydrate is used as a calcium channel and sodium channel protein inhibitor. It reduces electrical potential across tubular epithelium, inhibits angiogenesis and inhibits capillary morphogenesis completely and reversibly at approximately 130 ?M. Amiloride • HCl is an inhibitor of Sodium/Potassium-ATPase Protein. Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding Blocks TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger. Also inhibits urokinase-type plasminogen activator (uPA); has no effect on tissue-type plasminogen activator.

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Literaturverweise

Vassalli et al. Amiloride selectively inhibits the urokinase-type plasminogen activator. FEBS Lett.1987, 214, (1), 187-91.

Kleyman et al. Amiloride and its analogues as tools in the study of ion transport. J.Membr.Biol.1988, 105, (1), 1-21.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H301

Toxic if swallowed.

Sicherheitshinweise: P264-P270-P301+P310a-P321-P405-P501a

Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Specific treatment (see label). Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,406
Gefahrenklasse
6.1
Verpackungsgruppe
III
Harmonized Tariff Code
2933.99
TSCA
No
RTECS
UQ2275500

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