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Adenosine 3?,5?-cyclic monophosphate sodium salt monohydrate is used as an activator of protein kinase A (PKA) . A key regulator of many cellular reactions. Released in response to hormonal stimulation. . Directly activates Epac, a Rap1 guanine-nucleotide exchange factor. Acts as a second messenger in signal transduction mechanisms. Promotes apoptosis in resting human B lymphocytes.
W Epstein.; LB Rothman-Denes. Adenosine 3': 5'-cyclic monophosphate as mediator of catabolite repression in Escherichia coli. PNAS.1975, 72, (6), 2300-2304.
CM Szego.; JS Davis. Adenosine 3', 5'-monophosphate in rat uterus: acute elevation by estrogen. PNAS.1967, 58, (4), 1711-1718.