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17230-88-5 - Danazol - 17beta-Hydroxy-2,4,17a-pregnadien-20-yno[2,3-d]isoxazole - 2,4,17a-Pregnadien-20-yno[2,3-d]isoxazol-17-ol - J62200 - Alfa Aesar

J62200 Danazol

CAS-Nummer
17230-88-5
Synonyme
17beta-Hydroxy-2,4,17a-pregnadien-20-yno[2,3-d]isoxazole
2,4,17a-Pregnadien-20-yno[2,3-d]isoxazol-17-ol

Größe Preis ($) Menge Verfügbarkeit
100mg 50,16
500mg 217,33
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Danazol

MDL
MFCD00056838
EINECS
241-270-1

Chemische Eigenschaften

Formel
C22H27NO2
Molmasse
337.46
Form
Powder
Schmelzpunkt
218-220°
Löslichkeit
Partly soluble in water. Soluble in chloroform (25 mg/ml), acetone, acetonitrile, and ethanol. 17beta-Hydroxy-2,4,17a-pregnadien-20-yno[2,3-d]isoxazole and 2,4,17a-Pregnadien-20-yno[2,3-d]isoxazol-17-ol are the synonym of this compound.

Anwendungen

Danazol is a synthetic gonadotropin inhibitor which has a preventive effect on estrogen -related endometrial carcinogenesis in mice. Danazol therapy has also shown regression of established mammary carcinoma in rats. This medication is used in women to treat pelvic pain and infertility due to a certain uterus disorder (endometriosis) and also to treat breast pain/tenderness/nodules due to a certain breast condition (fibrocystic breast disease). It is also used in both men and women to prevent swelling of the abdomen/arms/legs/face/airway due to a certain congenital disease

Bemerkungen

Store at room temperature. Incompatible with oxidizing agents.

Literaturverweise

Gary G. Liversidge.; Kenneth C. Cundy. Particle size reduction for improvement of oral bioavailability of hydrophobic drugs: I. Absolute oral bioavailability of nanocrystalline danazol in beagle dogs.Int. J. Pharm. 1995, 125 (1),91-97 .

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H361-H312-H332

Suspected of damaging fertility or the unborn child. Harmful in contact with skin. Harmful if inhaled.

Sicherheitshinweise: P201-P261-P280-P281-P304+P340-P312-P363-P308+P313-P405-P501a

Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Use personal protective equipment as required. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Call a POISON CENTER or doctor/physician if you feel unwell. Wash contaminated clothing before reuse. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,2812
Harmonized Tariff Code
2937.29
TSCA
No
RTECS
TU4157070

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