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11089-65-9 - Tunicamycin, 95% - J62217 - Alfa Aesar

J62217 Tunicamycin, 95%

CAS-Nummer
11089-65-9
Synonyme

Größe Preis ($) Menge Verfügbarkeit
10mg 171,00
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Tunicamycin, 95%

MDL
MFCD00065709

Chemische Eigenschaften

Formel
C39H64N4O16
Molmasse
844.95
Form
Powder
Sensitivität
Moisture & Light Sensitive
Löslichkeit
Soluble in methanol, ethanol, DMSO, or DMF

Anwendungen

Tunicamycin has been widely used in the study of glycoprotein synthesis in various biological systems. During protein glycosylation, tunicamycin is noted to be an inhibitor of the transfer of saccharide moieties to dolichol during dolichol-linked glycoprotein synthesis. Dose-dependent inhibition of DNA synthesis may be related to the alteration of glycoproteins, which thereby affects the transport of thymidine into cells. Additionally, tunicamycin has been reported to prevent cell cycle progression in primary cultures of rat glial cells, as well as inhibit lipid-mediated protein glycosylation in chick or mouse fibroblasts in a dose-dependent manner.

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C Light sensitive. Moisture sensitive.

Literaturverweise

Ding et al. Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival. J.Biol.Chem. 2007, 282, (7), 4702-10.

Duriez et al. The hepatitis B virus precore protein is retrotransported from endoplasmic reticulum (ER) to cytosol through the ER-associated pathway. J.Biol.Chem. 2008, 283, (47), 32352-60.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H300-H330-H373

Fatal if swallowed. Fatal if inhaled. May cause damage to organs through prolonged or repeated exposure.

Sicherheitshinweise: P260-P284-P301+P310-P304+P340-P320-P330-P310-P405-P403+P233-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear respiratory protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Specific treatment is urgent (see label). Rinse mouth. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,9819
Beilstein
6888090
Gefahrenklasse
6.1
Verpackungsgruppe
II
Harmonized Tariff Code
2941.90
TSCA
No
RTECS
YO7980200

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