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1393-48-2 - Thiostrepton, Streptomyces laurentii, 90+% - Bryamycin - Thiactin - J62332 - Alfa Aesar

J62332 Thiostrepton, Streptomyces laurentii, 90+%

CAS-Nummer
1393-48-2
Synonyme
Bryamycin
Thiactin

Größe Preis ($) Menge Verfügbarkeit
1g 168,30
5g 614,40
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Thiostrepton, Streptomyces laurentii, 90+%

MDL
MFCD00135828
EINECS
215-734-9

Chemische Eigenschaften

Formel
C72H85O18N19S5
Molmasse
1664.89
Form
Powder
Löslichkeit
Soluble in DMSO or chloroform

Anwendungen

Thiostrepton exhibits antibiotic activity through blockade of ribosome turnover after an elongation step in protein synthesis by inhibiting both the dissociation of elongation factor G (EF-G) from the ribosome and the release of inorganic phosphate from EF-G following GTP hydrolysis. Thiostrepton is also described to show efficacy against cancer cell growth through downregulation of the forkhead box M1 (FOXM1) transcription factor, commonly overexpressed in many malignancies. Thiostrepton is an inhibitor of FOXM1. Thiostrepton has been used as a selectable marker for recombinant Streptomyces cultures.

Bemerkungen

Store at -20°C. Incompatible with oxidizing agents. Protect from heat.

Literaturverweise

Ursula Mocek.; Zhaopie Zeng.; David O'Hagan.; Pei Zho.; Lai Duen G. Fan.; John M. Beale.; Heinz G. Floss. Biosynthesis of the modified peptide antibiotic thiostrepton in Streptomyces azureus and Streptomyces laurentii.J. Am. Chem. Soc. 1993, 115 (18),7992-8001 .

Takahiro Suzuki.; Tsuneo Yamane.; Shoichi Shimizu. Mass production of thiostrepton by fed-batch culture of Streptomyces laurentii with pH-stat modal feeding of multi-substrate. . 1987, 25 (6),526-531 .

Weitere Referenzen

Merck
14,9364
Harmonized Tariff Code
2941.90
TSCA
No
RTECS
XN6300100

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