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59721-29-8 - Camostat methanesulfate, 98% - Camostat mesylate - J62362 - Alfa Aesar

J62362 Camostat methanesulfate, 98%

CAS-Nummer
59721-29-8
Synonyme
Camostat mesylate

Größe Preis ($) Menge Verfügbarkeit
100mg 341,00
500mg 477,00
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Camostat methanesulfate, 98%

MDL
MFCD00941410

Chemische Eigenschaften

Formel
C20H22N4O5.CH3SO3H
Molmasse
494.52
Form
Powder
Schmelzpunkt
164-168°
Löslichkeit
Soluble in water (100 mM), DMSO (100 mM), and ethanol (<1 mg/ml).

Anwendungen

It is used as a protease and Trypsin inhibitor. Furthermore it was found that this water induction and bicarbonate secretion increase was achieved via direct regulation of ductular cells of the dog pancreas. Other studies have shown Camostat mesylate to suppress spinal Fos expression in the rat, which is a marker for neuronal activation. In addition it was shown that this compound may prevent or depress pancreatitis-induced referred allodynia/hyperalgesia in rat models. Camostat mesylate has also demonstrated the ability to prevent Trypsin attack of microspheres, which causes the degradation product N-benzoyl-dl-arginine. Camostat mesylate is an inhibitor of KLK, plasminogen, Prothrombin and Trypsin.

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C. Keep away from strong oxidizing agents.

Literaturverweise

Horiuchi et al. Gabexate and camostat, synthetic proteinase inhibitors, as direct inducing factors of water and bicarbonate secretion in the isolated and blood-perfused dog pancreas. J.Pharmacol.Exp.Ther. 1990, 252(1), 320-6.

Ishikura et al. The proteinase inhibitor camostat mesilate suppresses pancreatic pain in rodents. Life Sci. 2007, 80(21), 1999-2004.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H303-H315-H319-H335

May be harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Sicherheitshinweise: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,1728
Gefahrenklasse
9
Verpackungsgruppe
III
Harmonized Tariff Code
2925.29
TSCA
No
RTECS
CY1571620

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