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56092-81-0 - Ionomycin, 98% - J62448 - Alfa Aesar

J62448 Ionomycin, 98%

CAS-Nummer
56092-81-0
Synonyme

Größe Preis ($) Menge Verfügbarkeit
1mg 67,10
5mg 248,00
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Ionomycin, 98%

MDL
MFCD06798385

Chemische Eigenschaften

Formel
C41H72O9
Molmasse
709.02
Form
Solution in ethanol
Löslichkeit
Soluble to 10 mM in Ethanol and to 10 mM in DMSO.

Anwendungen

Ionomycin free acid is a beneficial tool in research to raise intracellular calcium levels. Also this antibiotic can be used to study the calcium transport across the plasma membrane. It has been shown to induce central demyelination , inhibit adrenal bovine TREK-1 channels , and to regulate cell division of mature human B cells . It is used to study the effects of calcium flux on endoplasmic reticulum (ER) stress, mitochondrial stress and intrinsic apoptosis mechanisms. It is also used to stimulate the intracellular production of the cytokines, interferon, perforin, IL-2, and IL-4 usually in conjunction with PMA.

Bemerkungen

A 10mg/ml solution in ethanol

Literaturverweise

Liu and Hermann. Characterization of ionomycin as a calcium ionophore. J.Biol.Chem.. 1978, 253, (17), 5892-4.

Kaufmann et al. Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria. J.Biol.Chem.. 1980, 255, (7), 2735-9.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H225

Highly flammable liquid and vapour.

Sicherheitshinweise: P210-P280a-P240-P241-P303+P361+P353-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Wear protective gloves and eye/face protection. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
3642126
Gefahrenklasse
3
Verpackungsgruppe
II
Harmonized Tariff Code
2941.90
TSCA
No
RTECS
NO0600000

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