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31884-77-2 - Meclizine dihydrochloride monohydrate - J62464 - Alfa Aesar

J62464 Meclizine dihydrochloride monohydrate

CAS-Nummer
31884-77-2
Synonyme

Größe Preis ($) Menge Verfügbarkeit
1g 33,68
5g 157,59
10g 283,25
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Meclizine dihydrochloride monohydrate

MDL
MFCD00058199

Chemische Eigenschaften

Formel
C25H27ClN2•2HCl•H2O
Molmasse
481.89 (463.88anhy)
Form
Powder
Schmelzpunkt
210-213°
Löslichkeit
Insoluble in water.

Anwendungen

Antiemetic and H1-histamine receptor antagonistMeclizine dihydrochloride monohydrate acts as an antiemetic. It is also used for the prevention and treatment of nausea during pregnancy. In addition to this, it is used in radiation sickness, vomiting or dizziness associated with motion sickness.

Bemerkungen

Incompatible with heat and oxidizing agents.

Literaturverweise

Foo, W. Y. B.; Tay, H. Y.; Chan, E. C. Y.; Lau, A. J. Meclizine, a pregnane X receptor agonist, is a direct inhibitor and mechanism-based inactivator of human cytochrome P450 3A. Biochem. Pharmacol. 2015, 97 (3), 320-330.

Lau, A. J.; Yang, G.; Rajaraman, G.; Baucom, C. C.; Chang, T. K. H. Differential Effect of Meclizine on the Activity of Human Pregnane X Receptor and Constitutive Androstane Receptor. J. Pharmacol. Exp. Ther. 2011, 336 (3), 816-826.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H361-H302

Suspected of damaging fertility or the unborn child. Harmful if swallowed.

Sicherheitshinweise: P201-P281-P264-P270-P202-P301+P312-P308+P313-P330-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. Do not handle until all safety precautions have been read and understood. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF exposed or concerned: Get medical advice/attention. Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,5777
Harmonized Tariff Code
2933.59
TSCA
Yes

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