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7689-03-4 - Camptothecin - (S)-(+)-Camptothecin - J62523 - Alfa Aesar

J62523 Camptothecin

CAS-Nummer
7689-03-4
Synonyme
(S)-(+)-Camptothecin

Größe Preis ($) Menge Verfügbarkeit
250mg 70,10
1g 140,00
5g 561,00
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Camptothecin

MDL
MFCD00081076

Chemische Eigenschaften

Formel
C20H16N2O4
Molmasse
348.35
Form
Powder
Schmelzpunkt
260° dec.
Löslichkeit
Soluble in dimethyl sulfoxide, 0.1N sodium hydroxide and acetic acid. Insoluble in water.

Anwendungen

Camptothecin is used as a cytotoxic antitumor agent that inhibits topoisomerase I.Camptothecin shows remarkable anticancer activity based on preliminary clinical trials. Its analogues are used in cancer chemotherapy. Cyclodextrin-based polymer containing camptothecin is used in the investigational anti-cancer drug study.

Bemerkungen

Store in cool place. Incompatible with strong oxidizing agents.

Literaturverweise

Li, R.; Shu, C.; Wang, W.; Wang, X.; Li, H.; Xu, D.; Zhong, W. Encapsulation of 10-Hydroxy Camptothecin in Supramolecular Hydrogel as an Injectable Drug Delivery System. J. Pharm. Sci. 2015, 104 (7), 2266-2275.

Liu, Y. Q.; Li, W. Q.; Natschke, S. L. M.; Qian, K.; Yang, L.; Zhu, G. X.; Wu, X. B.; Chen, A. L.; Zhang, S. Y.; Nan, X.; Lee, K. H. Perspectives on Biologically Active Camptothecin Derivatives. Med Res Rev 2015, 35 (4), 753-789.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H301

Toxic if swallowed.

Sicherheitshinweise: P260-P201-P280-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,1735
Beilstein
631069
Gefahrenklasse
6.1
Verpackungsgruppe
III
Harmonized Tariff Code
2939.80
TSCA
No
RTECS
UQ492000

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