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76721-89-6 - DL-Thiorphan - DL-3-Mercapto-2-benzylpropanoylglycine - J62557 - Alfa Aesar

J62557 DL-Thiorphan

CAS-Nummer
76721-89-6
Synonyme
DL-3-Mercapto-2-benzylpropanoylglycine

Größe Preis ($) Menge Verfügbarkeit
25mg 311,00
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DL-Thiorphan

MDL
MFCD00058435

Chemische Eigenschaften

Formel
C12H15NOS
Molmasse
253.32
Form
Powder
Schmelzpunkt
135-137°
Löslichkeit
Soluble in ethanol at 50mg/ml

Anwendungen

Thiorphan has the ability to block the degradation of the luteinizing hormone releasing hormone (LHRH). At higher concentrations, (14 ?M) this compound has been shown to inhibit the activity of angiotensin-converting enzyme (ACE). Neprilysin is overexpressed in many forms of cancer and may play a role in protecting against Alzheimer’s disease.

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong acids, strong bases.

Literaturverweise

Amantini C et al. Thiorphan-induced survival and proliferation of rat thymocytes by activation of Akt/survivin pathway and inhibition of caspase-3 activity. J Pharmacol Exp Ther . 2008, 327, (1), 215-25.

Medja F et al. Thiorphan, a neutral endopeptidase inhibitor used for diarrhoea, is neuroprotective in newborn mice. Brain . 2006, 129, (pt 12), 3209-23.

Weitere Referenzen

Beilstein
4872101
Harmonized Tariff Code
2930.90
TSCA
No
RTECS
MC0596440

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