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1229-29-4 - Doxepin hydrochloride - 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepine hydrochloride - J62579 - Alfa Aesar

J62579 Doxepin hydrochloride

CAS-Nummer
1229-29-4
Synonyme
11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepine hydrochloride

Größe Preis ($) Menge Verfügbarkeit
1g 34,30
5g 131,84
25g 571,00
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Doxepin hydrochloride

MDL
MFCD00079135
EINECS
214-966-8

Chemische Eigenschaften

Formel
C19H21NO•HCl
Molmasse
315.84
Form
Powder
Schmelzpunkt
187-189°
Löslichkeit
Soluble in water (100 mM), chloroform (1:2), alcohol (1:1), methanol, and DMSO.

Anwendungen

It is a highly potent H1 histamine receptor antagonist (Kd = 310 pM) and tricyclic antidepressant that inhibits the reuptake of serotonin and norepinephrine and acts as an antagonist at histamine, serotonin, adrenergic, and muscarinic receptors with Ki values in the nanomolar range. Also binds to the H4 histamine receptor (pKi = 6.79). Used clinically to treat anxiety and depression.

Bemerkungen

Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Literaturverweise

Tran VT, et al. [3H]doxepin interactions with histamine H1-receptors and other sites in guinea pig and rat brain homogenates.Eur J Pharmacol.,1981,70(4), 501-9.

Luchins DJ. Review of clinical and animal studies comparing the cardiovascular effects of doxepin and other tricyclic antidepressants.Am J Psychiatry.,1983,140(8), 1006-9.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H301-H361

Toxic if swallowed. Suspected of damaging fertility or the unborn child.

Sicherheitshinweise: P201-P281-P264-P270-P301+P310-P308+P313-P321-P330-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF exposed or concerned: Get medical advice/attention. Specific treatment (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,3435
Gefahrenklasse
6.1
Verpackungsgruppe
III
Harmonized Tariff Code
2932.99
TSCA
No
RTECS
HQ4375000

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