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40796-97-2 - 3-Tropanyl-3,5-dichlorobenzoate, 99+% - MDL-72222 - Bemesetron - J62583 - Alfa Aesar

J62583 3-Tropanyl-3,5-dichlorobenzoate, 99+%

CAS-Nummer
40796-97-2
Synonyme
MDL-72222
Bemesetron

Größe Preis ($) Menge Verfügbarkeit
50mg 232,00
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3-Tropanyl-3,5-dichlorobenzoate, 99+%

MDL
MFCD00865533

Chemische Eigenschaften

Formel
C15H17Cl2NO2
Molmasse
314.21
Form
Powder
Löslichkeit
Soluble to 100 mM in DMSO. Insoluble in water. Sparingly soluble in chloroform, and ethanol.

Anwendungen

It is most often used to study the role of SR-3. Studies suggest the blockade of SR-3 with may ameliorate beta-amyloid protein-induced neurotoxicity by interfering with the increase of Ca2+, and then by inhibiting glutamate release, generation of reactive oxygen species and caspase-3 activity. It is also used in the study of dopamine elevation in rats due to cocaine and amphetamine consumption.

Bemerkungen

Soluble to 100 mM in DMSO. Insoluble in water.

Literaturverweise

Fozard JR, et al. MDL 72222: a potent and highly selective antagonist at neuronal 5-hydroxytryptamine receptors.Naunyn Schmiedebergs Arch Pharmacol.,1984,326(1), 36-44.

Kankaanpää A, et al. 5-HT3 receptor antagonist MDL 72222 dose-dependently attenuates cocaine- and amphetamine-induced elevations of extracellular dopamine in the nucleus accumbens and the dorsal striatum.Pharmacol Toxicol.,1996,78(5), 317-21.

Weitere Referenzen

Harmonized Tariff Code
2939.99
TSCA
No
RTECS
DG7580000

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Chemikalien

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Metalle und Stoffe

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