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298-46-4 - Carbamazepine, 98% - 5H-Dibenz[b,f]azepine-5-carboxamide - J62590 - Alfa Aesar

J62590 Carbamazepine, 98%

CAS-Nummer
298-46-4
Synonyme
5H-Dibenz[b,f]azepine-5-carboxamide

Größe Preis ($) Menge Verfügbarkeit
25g 95,00
100g 289,00
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Carbamazepine, 98%

MDL
MFCD00005073
EINECS
206-062-7

Chemische Eigenschaften

Formel
C15H12N2O
Molmasse
236.27
Form
Powder
Schmelzpunkt
189-192°
Löslichkeit
Soluble in ethanol, acetone, propylene glycol, chloroform, dimethyl sulfoxide, methanol, dimethyl fluoride,ethylene glycol and monoethyl ether. Slightly soluble in glacial acetic acid. Insoluble in water.

Anwendungen

Carbamazepine is used as cytochrome P450 3A4 inducing anti-epileptic drug and ligand for the GABA-A receptor benzodiazepine modulatory site. Carbamazepine is typically used for the treatment of seizure disorders and neuropathic pain. It is associated with other medications and used to treat schizophrenia as well as a second line agent in bipolar disorders.

Bemerkungen

Store in cool place. Incompatible with strong oxidizing agents.

Literaturverweise

Tolbert, D.; Cloyd, J.; Biton, V.; Bekersky, I.; Walzer, M.; Wesche, D.; Drummond, R.; Lee, D. Bioequivalence of oral and intravenous carbamazepine formulations in adult patients with epilepsy. Epilepsia. 2015, 56 (6), 915-923.

Shokry, E.; Villanelli, F.; Malvagia, S.; Rosati, A.; Forni, G.; Funghini, S.; Ombrone, D.; Bona, M. D.; Guerrini, R.; Marca, G. L. Therapeutic drug monitoring of carbamazepine and its metabolite in children from dried blood spots using liquid chromatography and tandem mass spectrometry. J. Pharm. Biomed. Anal. 2015, 109, 164-170.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H302-H334-H317

Harmful if swallowed. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction.

Sicherheitshinweise: P284-P261-P280g-P342+P311a-P301+P312a-P501a

Wear respiratory protection. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves. If experiencing respiratory symptoms: IF SWALLOWED: Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,1781
Harmonized Tariff Code
2933.99
TSCA
No
RTECS
HN8225000

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