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An alpha-glucosidase inhibitor. Interferes with normal processing of N-linked glycoproteins.(+)-1-Deoxynojirimycin acts as an inhibitor of alfa-glucosidase I and II and maltase-glucoamylase. It also inhibits mammalian glucosidase, intestinal and lysosmal, beta-glucosidase from sweet almonds, pancreatic alfa-amylase and amyloglucosidase. Further, it serves as a enzyme enhancer for the treatment of Fabry and Pompe disease.
Liu, C.; Xiang, W.; Yu, Y.; Shi, Z. Q.; Huang, X. Z.; Xu, L. Comparative analysis of 1-deoxynojirimycin contribution degree to alpha-glucosidase inhibitory activity and physiological distribution in Morus alba L. Ind. Crops Prod. 2015, 70, 309-315.
Park, S. H.; Kim, J. Y.; Kim, J. S.; Jung, C.; Song, D. K.; Ham, W. H. 1,3-Oxazine as a chiral building block used in the total synthesis of (+)-1-deoxynojirimycin and (2R,5R)-dihydroxymethyl-(3R,4R)-dihydroxypyrrolidine. Tetrahedron: Asymmetry 2015, 26 (12-13), 657-661.
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