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15307-79-6 - Diclofenac sodium salt - 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt - Sodium 2-(2,6-dichloroanilino)phenylacetate - J62609 - Alfa Aesar

J62609 Diclofenac sodium salt

CAS-Nummer
15307-79-6
Synonyme
2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt
Sodium 2-(2,6-dichloroanilino)phenylacetate

Größe Preis ($) Menge Verfügbarkeit
5g 27,40
25g 61,80
100g 193,00
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

Diclofenac sodium salt

MDL
MFCD00082251
EINECS
239-346-4

Chemische Eigenschaften

Formel
C14H10Cl2NNaO2
Molmasse
318.14
Form
Powder
Schmelzpunkt
283-285°
Löslichkeit
Soluble in water to 50mg/ml.

Anwendungen

Oxidation of diclofenac sodium produces the metabolite 4'-hydroxy diclofenac) which demonstrates specific inhibition of Cox-2. Inhibition of Cox by diclofenac and 4'-hydroxy diclofenac suppresses prostaglandin E2 synthesis, producing anti-inflammatory and analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils, preventing the formation of insoluble amyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9. It is also used as an inhibitor of Cox-1 and Cox-2.

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Literaturverweise

Barnett, J., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim. Biophys. Acta. 1994, 1209, (1), 130-9.

Laneuville, O., et al. Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. J. Pharmacol. Exp. Ther. 1994, 271, (2), 927-34.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H301-H361

Toxic if swallowed. Suspected of damaging fertility or the unborn child.

Sicherheitshinweise: P260-P201-P280-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,3081
Gefahrenklasse
6.1
Verpackungsgruppe
III
Harmonized Tariff Code
2922.49
TSCA
No
RTECS
AG6330000

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