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546-06-5 - Conessine, 97% - Neriine - Roquessine - J62617 - Alfa Aesar

J62617 Conessine, 97%

CAS-Nummer
546-06-5
Synonyme
Neriine
Roquessine

Größe Preis ($) Menge Verfügbarkeit
100mg 77,15
250mg 154,50
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Conessine, 97%

MDL
MFCD00016752
EINECS
208-897-2

Chemische Eigenschaften

Formel
C24H40N2
Molmasse
356.59
Form
Powder
Schmelzpunkt
125-127°
Löslichkeit
Soluble to 50 mM in ethanol and to 50 mM in DMSO with gentle warming.

Anwendungen

It have been used in traditional herbal medicine as a treatment for amoebic dysentery. In a radioligand-based high-throughput screen, conessine demonstrated high affinity for both rat and human histamine H3 receptors (Kis = 5.2 and 24.5 nM, respectively) and high selectivity against histamine receptors H1, H2, and H4.1 Though conessine potently blocks H3 agonist-stimulated GTPγS binding in cell- and tissue-based functional assays and efficiently crosses the blood-brain barrier, it has a poor rate of CNS clearance.

Bemerkungen

Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Literaturverweise

Zhao, C, et al. The alkaloid conessine and analogues as potent histamine H3 receptor antagonists. Med Chem.,2008,515423-5430.

Siddiqui BS, et al. Antimicrobial activity of the methanolic bark extract of Holarrhena pubescens (Buch. Ham), its fractions and the pure compound conessine.Natural product research.,2012,26(11), 987-992.

Weitere Referenzen

Merck
14,2497
Harmonized Tariff Code
2939.99
TSCA
No

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