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62996-74-1 - Staurosporine, 99+% - Antibiotic AM-2282 - J62837 - Alfa Aesar

J62837 Staurosporine, 99+%

CAS-Nummer
62996-74-1
Synonyme
Antibiotic AM-2282

Größe Preis ($) Menge Verfügbarkeit
1mg 113,30
5mg 294,58
10mg 554,14
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Staurosporine, 99+%

MDL
MFCD00077402

Chemische Eigenschaften

Formel
C28H26N4O3
Molmasse
466.54
Form
Powder
Schmelzpunkt
240-243°
Löslichkeit
Soluble in DMSO or ethanol.Soluble in dimethyl sulfoxide , dimethyl formamide, ethyl acetate, hot acetone and ethanol. Slightly soluble in chloroform and methanol. Insoluble in water.

Anwendungen

Broad spectrum protein kinase inhibitor Staurosporine is used as anti-fungal and anti-hypertensive, which results to study the anti-cancer treatment. It acts as a precursor to protein kinase inhibitor midostaurin. It is also used to induce cell death in Swiss Webster primary macrophage cells and to study the effect of caspase activation on human sperm quality.

Bemerkungen

Store in a cool place. Incompatible with strong oxidizing agents.

Literaturverweise

Kohno, T.; Ninomiya, T.; Kikuchi, S.; Konno, T.; Kojima, T. Staurosporine Induces Formation of Two Types of Extra-Long Cell Protrusions: Actin-Based Filaments and Microtubule-Based Shafts. Mol. Pharmacol. 2015, 87 (5), 815-824.

Lee, H. G.; Kim, D. S.; Moon, S. A.; Kang, J. W.; Seo, J. T. Staurosporine Induces ROS-Mediated Process Formation in Human Gingival Fibroblasts and Rat Cortical Astrocytes. Int. J. Oral Biol. 2015, 40 (1), 27-33.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H350

May cause cancer.

Sicherheitshinweise: P201-P281-P202-P308+P313-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Do not handle until all safety precautions have been read and understood. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,8802
Beilstein
1060573
Harmonized Tariff Code
2934.99
TSCA
No
RTECS
KD5084000

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