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J62917 Midostaurin

CAS-Nummer
120685-11-2
Synonyme
PKC412
4'-N-Benzoylstaurosporine

Stock No. Größe Preis ($) Menge Verfügbarkeit
J62917-M^ 1mg 106,00
J62917-#0 5mg 387,00
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Midostaurin

MDL
MFCD12828879

Chemische Eigenschaften

Formel
C35H30N4O4
Molmasse
570.64
Form
Powder
Schmelzpunkt
235-260°
Storage & Sensitivity
Store at -20°C.
Löslichkeit
Soluble in DMSO (15 mg/ml), MDC (10 mg/ml), methanol (5 mg/ml), 100% ethanol (2.5 mg/ml), and DMF (20 mg/ml).

Anwendungen

Midostaurin is used as a broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms (α, β, γ), PDFRβ, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity. Due to this act which may result in disruption of the cell cycle, inhibition of proliferation, apoptosis, and inhibition of angiogenesis in susceptible tumors. Midostaurin was shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit.

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from Strong acids, oxidizing agents, bases.

Literaturverweise

Fabbro et al. PKC412 - a protein kinase inhibitor with a broad therapeutic potential. Anticancer Drug Des. 200015 (1), 17-28.

Tenzer et al. The phosphatidylinositide 3'-kinase/Akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C. Cancer Res. 200161 (22), 8203-10.

Weitere Referenzen

Merck
14,6185
Harmonized Tariff Code
2934.99
TSCA
No

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