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66701-25-5 - E-64 - trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane - J62933 - Alfa Aesar

J62933 E-64

CAS-Nummer
66701-25-5
Synonyme
trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane

Größe Preis ($) Menge Verfügbarkeit
5mg 97,34
25mg 404,79
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E-64

MDL
MFCD00080261

Chemische Eigenschaften

Formel
C15H27N5O5
Molmasse
357.40
Form
Powder
Sensitivität
Light Sensitive
Löslichkeit
Soluble in DMSO (25mg/ml), or water (20mg/ml)

Anwendungen

It is used as a broad spectrum cysteine proteinase and calpain activation inhibitor. Additionally, Prevotella intermediate studies report that E-64 blocks the breakdown of methaemoglobin and the oxidation of oxyhaemoglobin by InpA. E-64 has also been used to study excystation in Giardia lamblia. E-64 is an inhibitor of Calpain, cathepsin K and cathepsin S. E-64 is an effective ligand for affinity purification of cysteine proteases. When coupled to a thiolated affinity matrix, binding is no longer irreversible, but specificity is retained

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away from strong acids, strong bases.

Literaturverweise

Susa et al. Human primary osteoclasts: in vitro generation and applications as pharmacological and clinical assay. J.Transl.Med. 2004, 2, (1), 6-9.

Zhao et al. Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity. Nat.Cell.Biol. 2010, 12, (7), 665-75.

Weitere Referenzen

Beilstein
1405664
Harmonized Tariff Code
2925.29
TSCA
No
RTECS
RR0390000

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