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96829-58-2 - Orlistat, 98% - (-)-Tetrahydrolipstatin - Ro-18-0647 - J62999 - Alfa Aesar

J62999 Orlistat, 98%

CAS-Nummer
96829-58-2
Synonyme
(-)-Tetrahydrolipstatin
Ro-18-0647

Größe Preis ($) Menge Verfügbarkeit
50mg 60,15
100mg 113,30
250mg 219,97
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Orlistat, 98%

MDL
MFCD05662360

Chemische Eigenschaften

Formel
C29H53NO5
Molmasse
495.73
Form
Solid
Schmelzpunkt
<50°
Löslichkeit
Soluble in DMSO (19 mg/mL), ethanol (20 mg/mL), and DMF (20 mg/mL).

Anwendungen

Orlistat, used in obesity research, is a pancreatic lipase inhibitor that acts locally in the gastrointestinal tract to inhibit lipase. More detailed experiments show that gradually THL affects the retinoblastoma protein pathway and leads to cell-cycle arrest at G1/S boundary. Lipase Inhibitor, THL is an inhibitor of pancreatic and gastric lipase, as well as carboxyl ester lipase (CEL) and diacylglycerol lipase-&#945; (DAGL&#945;). Lipase Inhibitor, THL also activates caspase-3.

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away from strong oxidizing agents.

Literaturverweise

Khedidja B & Abderrahman L Selection of orlistat as a potential inhibitor for lipase from Candida species. Bioinformation.2011, 7, (3), 125-9.

Kridel SJ et al. Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity. Cancer Res.2011, 64, (6), 2070-5 .

Weitere Referenzen

Merck
14,6869
Harmonized Tariff Code
2932.20
TSCA
No
RTECS
OH3167600

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