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Orlistat, used in obesity research, is a pancreatic lipase inhibitor that acts locally in the gastrointestinal tract to inhibit lipase. More detailed experiments show that gradually THL affects the retinoblastoma protein pathway and leads to cell-cycle arrest at G1/S boundary. Lipase Inhibitor, THL is an inhibitor of pancreatic and gastric lipase, as well as carboxyl ester lipase (CEL) and diacylglycerol lipase-α (DAGLα). Lipase Inhibitor, THL also activates caspase-3.
Khedidja B & Abderrahman L Selection of orlistat as a potential inhibitor for lipase from Candida species. Bioinformation.2011, 7, (3), 125-9.
Kridel SJ et al. Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity. Cancer Res.2011, 64, (6), 2070-5 .