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738-70-5 - Trimethoprim - 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine - J63053 - Alfa Aesar

J63053 Trimethoprim

CAS-Nummer
738-70-5
Synonyme
2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine

Größe Preis ($) Menge Verfügbarkeit
1g 26,06
5g 69,63
25g 278,10
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Trimethoprim

MDL
MFCD00036761
EINECS
212-006-2

Chemische Eigenschaften

Formel
C14H18N4O3
Molmasse
290.32
Form
Powder
Schmelzpunkt
199-203°
Löslichkeit
Trimethoprim is soluble in water at 0.4 mg/ml. It is also soluble in DMSO at 50 mg/ml and chloroform at 18.2 mg/ml. Soluble in methanol, chloroform, dimethyl sulfoxide, N,N-dimethylacetamide, benzyl alcohol, and propylene glycol. Insoluble in water, diethyl ether and benzene.

Anwendungen

An antibacterial and inhibitor of formylation. Dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.Trimethoprim is an antibiotic involved in the treatment of urinary tract infections, middle ear infections and traveler’s diarrhea. It is associated with sulfamethoxazole and interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Furthermore, It is also used to treat and prevent Pneumocystis jiroveci pneumonia.

Bemerkungen

Sensitive to light. Incompatible with strong oxidizing agents. Sore in a cool place.

Literaturverweise

Moreira, F. C.; Boaventura, R. A.; Brillas, E.; Vilar, V. J. Degradation of trimethoprim antibiotic by UVA photoelectro-Fenton process mediated by Fe(III)-carboxylate complexes. Appl. Catal., B 2015, 162, 34-44.

Felix, J. P. F.; Lira, R. P. C.; Zacchia, R. S.; Toribio, J. M.; Nascimento, M. A.; Arieta, C. E. L. Trimethoprim-sulfamethoxazole versus placebo to reduce the risk of recurrences of Toxoplasma gondii retinochoroiditis: randomized controlled clinical trial. Am. J. Ophthalmol. 2014, 157 (4), 762-766.

Weitere Referenzen

Merck
14,9709
Beilstein
625127
Harmonized Tariff Code
2933.59
TSCA
No
RTECS
UV8225000

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