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An antibacterial and inhibitor of formylation. Dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.Trimethoprim is an antibiotic involved in the treatment of urinary tract infections, middle ear infections and travelers diarrhea. It is associated with sulfamethoxazole and interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Furthermore, It is also used to treat and prevent Pneumocystis jiroveci pneumonia.
Moreira, F. C.; Boaventura, R. A.; Brillas, E.; Vilar, V. J. Degradation of trimethoprim antibiotic by UVA photoelectro-Fenton process mediated by Fe(III)-carboxylate complexes. Appl. Catal., B 2015, 162, 34-44.
Felix, J. P. F.; Lira, R. P. C.; Zacchia, R. S.; Toribio, J. M.; Nascimento, M. A.; Arieta, C. E. L. Trimethoprim-sulfamethoxazole versus placebo to reduce the risk of recurrences of Toxoplasma gondii retinochoroiditis: randomized controlled clinical trial. Am. J. Ophthalmol. 2014, 157 (4), 762-766.