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Bradykinin is used to lower blood pressure, increase bradykinin (by inhibiting its degradation) further lowering blood pressure. Bradykinin dilates blood vessels via the release of prostacyclin, nitric oxide, and endothelium-derived hyperpolarizing factor.
Regoli et al. Bradykinin receptors and their antagonists. Eur.J.Pharmacol. 1998348 (1), 1-10.
Leeb-Lundberg et al. International union of pharmacology XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol.Rev. 200557 (1), 27-77.
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