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59865-13-3 - Cyclosporin A, 99+% - Cyclosporine A - Antibiotic S 7481F1 - J63191 - Alfa Aesar

J63191 Cyclosporin A, 99+%

CAS-Nummer
59865-13-3
Synonyme
Cyclosporine A
Antibiotic S 7481F1

Größe Preis ($) Menge Verfügbarkeit
1g 173,04
5g 381,10
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Cyclosporin A, 99+%

MDL
MFCD00274558
EINECS
611-907-1

Chemische Eigenschaften

Formel
C62H111N11O12
Molmasse
1202.61
Form
Crystalline solid
Schmelzpunkt
146-151°
Löslichkeit
Soluble in dimethyl sulfoxide and ethanol. Insoluble in water.

Anwendungen

Ciclosporin A induces apoptosis and inhibits angiogenesis induced by VEGF.Cyclosporin A is used as dermatologic drug to treat rheumatoid arthritis and prevent skin disorders. It acts as an immunosuppressive agent, which suppresses the immune function. It finds application as an anti-asthmatic drug to treat asthma. It also suppresses the replication of hepatitis C virus genome in cultured hepatocytes.

Bemerkungen

Store in cool place. Incompatible with alkali metals, aluminum and strong oxidizing agents.

Literaturverweise

Staudinger, L. A.; Spano, S. J.; Lee, W. S.; Coelho, N.; Moriarty, T. J.; McCulloch, C. A. Role of discoidin domain receptor 1 in dysregulation of collagen remodeling by cyclosporin A. Int. J. Biochem. Cell Biol. 2015, 62, 80-87.

Petrillo, C.; Cesana, D.; Piras, F.; Bartolaccini, S.; Naldini, L.; Montini, E.; Rudnitski, A. K. Cyclosporin A and Rapamycin Relieve Distinct Lentiviral Restriction Blocks in Hematopoietic Stem and Progenitor Cells. Molecular Therapy 2015, 23 (2), 352-362.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H350-H360-H302

May cause cancer. May damage fertility or the unborn child. Harmful if swallowed.

Sicherheitshinweise: P201-P281-P264-P270-P202-P301+P312-P308+P313-P330-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. Do not handle until all safety precautions have been read and understood. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF exposed or concerned: Get medical advice/attention. Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,2752
Beilstein
3647785
Harmonized Tariff Code
2941.90
TSCA
No
RTECS
GZ4120000

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