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Thrombin is a trypsin-like serine protease involved in a multitude of processes in the human body. Thrombin generation is the result of limited proteolysis of the vitamin K-dependent zymogen prothrombin. Thrombin is the last enzyme in the clotting cascade functioning to cleave fibrinogen to fibrin which forms the fibrin gel of a haemostatic plug or a pathologic thrombus
Walter Kisiel.; William M. Canfield.; Lowell H. Ericsson.; Earl W. Davie. Anticoagulant properties of bovine plasma protein C following activation by thrombin.Biochemistry.1977, 16, (26), 5824-5831.
Walter Kisiel. Human plasma protein c: isolation, characterization, and mechanism of activation by α-thrombin.J Clin Invest.1979, 64, (3), 761-769..
Gefahrenhinweise (EU): H315-H319-H334-H335
Causes skin irritation. Causes serious eye irritation. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause respiratory irritation.
Wear respiratory protection. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.