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76420-72-9 - Enalaprilat - Enalaprilic acid - J63392 - Alfa Aesar

J63392 Enalaprilat

CAS-Nummer
76420-72-9
Synonyme
Enalaprilic acid

Größe Preis ($) Menge Verfügbarkeit
10mg 114,41
50mg 208,98
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Enalaprilat

MDL
MFCD00865786
EINECS
278-459-3

Chemische Eigenschaften

Formel
C18H28N2O7
Molmasse
384.42
Form
Crystalline solid
Schmelzpunkt
148-151°
Löslichkeit
Soluble in water with heating (~60°C)

Anwendungen

Enalapril is a ACE (angiotensin-converting enzyme) inhibitor, suggested to be more potent than Captopril (sc-200566). Studies indicate that Enalapril downregulates the expression of IL-β, IL-6, and NF-κB. Further studies show that Enalapril upregulates the expression of VEGF and heme oxygenase-1. Enalaprilat reports demonstrate that the compound has some antioxidant activity, which does not include the PKC-NADPH oxidase pathway.

Bemerkungen

Store in a cool dry place. Keep away from oxidizing agents.

Literaturverweise

P. Ahlin.; J. Kristl.; A. Kristl; F. Vrečer. Investigation of polymeric nanoparticles as carriers of enalaprilat for oral administration.Int. J. Pharm. 2002, 239 (1-2),113-120 .

Peter W Swaan.; Marco C Stehouwer.; Josef J Tukker. Molecular mechanism for the relative binding affinity to the intestinal peptide carrier. Comparison of three ACE-inhibitors: enalapril, enalaprilat, and lisinopril.Biochimica et Biophysica Acta (BBA) - Biomembranes. 1995, 1236 (1),31-38 .

Weitere Referenzen

Merck
14,3568
Harmonized Tariff Code
2933.99
TSCA
No

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