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Geldanamycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins. It interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.
S. Mark Roe.; Chrisostomos Prodromou.; Ronan O'Brien.; John E. Ladbury.; Peter W. Piper.; Laurence H. Pearl. Structural Basis for Inhibition of the Hsp90 Molecular Chaperone by the Antitumor Antibiotics Radicicol and Geldanamycin.J. Med. Chem. 1999, 42 (2),260-266 .
Gefahrenhinweise (EU): H303
May be harmful if swallowed.