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10540-29-1 - Tamoxifen, 98% - cis-1-(4-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene - J63509 - Alfa Aesar

J63509 Tamoxifen, 98%

CAS-Nummer
10540-29-1
Synonyme
cis-1-(4-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene

Größe Preis ($) Menge Verfügbarkeit
500mg 84,50
1g 143,00
5g 632,00
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Tamoxifen, 98%

MDL
MFCD00010454
EINECS
234-118-0

Chemische Eigenschaften

Formel
C26H29NO
Molmasse
371.52
Form
Powder
Löslichkeit
Insoluble in water. Soluble in methanol, ethanol, propanol or propylene glycol.Soluble in dimethyl sulfoxide, dichloromethane and ethanol. Insoluble in water.

Anwendungen

Inhibitor of protein kinase C and induces apoptosis in cancer cells Tamoxifen is used in the treatment of both early and advanced estrogen receptor positive breast cancer in pre- and post-menopausal women. It is also used in the treatment of infertility in women with anovulatory disorders as well as to prevent estrogen-related gynecomastia. It is utilized in the study on lipopolysaccharide (LPS)-induced microglial activation to know its effect.

Bemerkungen

Light sensitive. Store in a cool place. Incompatible with strong oxidizing agents.

Literaturverweise

Mikelman, S.; Guptaroy, B.; Jutkiewicz, E.; Gnegy, M. The Protein Kinase C Inhibitor Tamoxifen Inhibits Neurochemical and Reinforcing Behavioral Effects of Amphetamine. FASEB J. 2015, 29 (1), 930-1011.

Chlebowski, R. T. IBIS-I tamoxifen update: maturity brings questions. Lancet Oncol. 2015, 16 (1), 7-9.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H350-H360-H362

May cause cancer. May damage fertility or the unborn child. May cause harm to breast-fed children.

Sicherheitshinweise: P263-P260u-P201-P280-P405-P501a

Avoid contact during pregnancy/while nursing. Do not breathe dusts or mists. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,9048
Harmonized Tariff Code
2922.29
TSCA
No
RTECS
KR5919600

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