Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

103745-39-7 - Fasudil, 98+% - HA-1077 - J63525 - Alfa Aesar

J63525 Fasudil, 98+%

CAS-Nummer
103745-39-7
Synonyme
HA-1077

Größe Preis ($) Menge Verfügbarkeit
10mg 139,05
50mg 479,20
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

Fasudil, 98+%

MDL
MFCD00866182

Chemische Eigenschaften

Formel
C14H17N3O2S
Molmasse
327.83
Form
Crystalline powder
Löslichkeit
Soluble in water or DMSO

Anwendungen

HA-1077 dihydrochloride has been shown to be a vasodilating agent as well as a potent inhibitor of Rock-2 (Rho-associated Kinase II), cGKI (cGMP-dependent protein kinase), PKA (cAMP-dependent protein kinase), MYLK, and CaMKII. Rho kinase signaling pathways are thought to cause invasion, migration, and proliferation of certain cells. Studies have shown this compound can also inhibit myosin light chain kinase in vitro and suppress cell rounding by myosin light chain phosphorylation. Mechanistic experiments report that HA-1077 inhibits vascular smooth muscle contraction by acting as a calcium channel protein inhibitor. HA-1077 dihydrochloride is an inhibitor of MSK1, PKC, PRK2 and Rsk-2.

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents.

Literaturverweise

Wickman, G., C. Lan.; and B. Vollrath. Functional roles of the rho/rho kinase pathway and protein kinase C in the regulation of cerebrovascular constriction mediated by hemoglobin: relevance to subarachnoid hemorrhage and vasospasm. Circ Res. 201292 (7), 809-16.

Weitere Referenzen

Merck
14,3942
Harmonized Tariff Code
2935.00
TSCA
No

Empfohlen

  • 12613

    Sodium selenate, anhydrous, 99.8+% (metals basis)

Kürzlich angesehen

Chemikalien

Life science

Metalle und Stoffe

Katalysatoren

Forschungs- und Laborbedarf