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It shows hypocalcaemic and hypophosphatemic action, with amino-acid structure differing amongst mammalian species. Salmon calcitonin (salcatonin is the synthetic analogue) shows a markedly different sequence to that of the higher vertebrates as well as more potent activity. It decreases blood calcium and phosphate due to inhibition of resorption by osteoblasts and osteocytes.
R J Schlueter; A L Caldwell. Thyrocalcitonin: parameters of bio-assay. Endocrinology. 1967, 81 (4), 854-860.
J R Farley; N M Tarbaux; S L Hall; T A Linkhart; D J Baylink. The anti-bone-resorptive agent calcitonin also acts in vitro to directly increase bone formation and bone cell proliferation. Endocrinology.1988, 123 (1),159-167.