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104987-11-3 - Tacrolimus, 99+% - FK-506 - Fugimycin - J63571 - Alfa Aesar

J63571 Tacrolimus, 99+%

CAS-Nummer
104987-11-3
Synonyme
FK-506
Fugimycin

Größe Preis ($) Menge Verfügbarkeit
50mg 154,00
100mg 253,00
500mg 660,00
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

Tacrolimus, 99+%

MDL
MFCD11045918

Chemische Eigenschaften

Formel
C44H69NO12
Molmasse
804.02
Form
Powder
Schmelzpunkt
120-125°
Löslichkeit
Freely soluble in DMSO or ethanol. Poorly soluble in water.Soluble in dimethyl sulfoxide, ethanol, water, acetone, chloroform, ethyl acetate, ether, methanol and dimethyl formamide.

Anwendungen

Interacts with the immunophilins cyclophilin and FKBP-12.Tacrolimus is used as an immunosuppressive drug that blocks T cell proliferation in vitro. It is also used in the treatment of other T cell-mediated diseases such as eczema, Kimura's disease and Cushing's syndrome. Further, it is used as a research tool in chemically induced dimerization applications. In addition, it is used in liver transplantation and to suppress the inflammation in ulcerative cells. In dermatology, it is used as an ointment to treat eczema especially atopic dermatitis.

Bemerkungen

Incompatible with strong oxidizing agents.

Literaturverweise

Chapron, B.; Risler, L.; Phillips, B.; Collins, C.; Thummel, K.; Shen, D. Reversible, Time-Dependent Inhibition of CYP3A-Mediated Metabolism of Midazolam and Tacrolimus by Telaprevir in Human Liver Microsomes. J. Pharm. Pharm. Sci. International 2015, 18 (1), 101-111.

Staatz, C. E.; Tett, S. E. Clinical pharmacokinetics of once-daily tacrolimus in solid-organ transplant patients. Clin Pharmacokinet 2015, 54 (10), 993-1025.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H301

Toxic if swallowed.

Sicherheitshinweise: P264-P270-P301+P310a-P321-P405-P501a

Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Specific treatment (see label). Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,9025
Gefahrenklasse
6.1
Verpackungsgruppe
III
Harmonized Tariff Code
2934.99
TSCA
No
RTECS
KD4200000

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