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Thiamphenicol is used to treat chancroid in men and uncomplicated gonorrhea. It is used in studies of bacterial protein synthesis at the level of peptidyl transferase activity associated with the 23S rRNA of the 50S ribosomal subunit. It is used to study chloraniphenicol-thiamphenicol-resistance and the use of fluorinated analogs when resistance is encountered. Its main advantage over chloramphenicol is that it has never been associated with aplastic anaemia.
Tomoko Nagata.; Hisao Oka. Detection of Residual Chloramphenicol, Florfenicol, and Thiamphenicol in Yellowtail Fish Muscles by Capillary Gas Chromatography-Mass Spectrometry.J. Agric. Food Chem.1996, (5), 1280-1284.
Franklin A Davis.; Ping Zhou. Asymmetric synthesis of the antibiotic (+)-thiamphenicol using cis-N-(p-toluenesulfinyl)aziridine 2-carboxylic acids.Tetrahedron Letters.1994, (41), 7525-7528.
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