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Anticancer agent; microtubule disrupter; Induces apoptosis.Vinblastine sulfate is therapeutically used as an antineoplastic. It is also used in the treatment of Hodgkin disease, choriocarcinoma, acute and chronic leukemias.
Lee, C. T.; Huang, Y. W.; Yang, C. H.; Huang, K. S. Drug Delivery Systems and Combination Therapy by Using Vinca Alkaloids. Curr. Top. Med. Chem. 2015, 15 (15), 1491-1500.
Chen, Q.; Bian, Y.; Zeng, S. Involvement of AP-1 and NF-κB in the Up-regulation of P-gp in Vinblastine Resistant Caco-2 Cells. Drug Metab. Pharmacokinet. 2014, 29 (2), 223-226.
Gefahrenhinweise (EU): H302-H315-H318-H335
Harmful if swallowed. Causes skin irritation. Causes serious eye damage. May cause respiratory irritation.
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.