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58-54-8 - Ethacrynic acid - (2,3-Dichloro-4-[2-methylenebutyryl]phenoxy)acetic acid - J63684 - Alfa Aesar

J63684 Ethacrynic acid

CAS-Nummer
58-54-8
Synonyme
(2,3-Dichloro-4-[2-methylenebutyryl]phenoxy)acetic acid

Ethacrynic acid

MDL
MFCD00056693
EINECS
200-384-1

Chemische Eigenschaften

Formel
C13H12Cl2O4
Molmasse
303.14
Form
Crystalline powder
Löslichkeit
Soluble in ethanol, chloroform, ether, ammonia, carbonates, and methanol. Insoluble in water.

Anwendungen

Ethacrynic acid is used to inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.

Bemerkungen

Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literaturverweise

Maurice Burg.; Nordica Green. Effect of ethacrynic acid on the thick ascending limb of Henle's loop. Kidney International. 1973, 4, 301-308.

Sanjay Awasthi.; Sanjay K. Srivastava.; Faiyaz Ahmad.; Hassan Ahmad.; Ansari, G.A.S. Interactions of glutathione S-transferase-π with ethacrynic acid and its glutathione conjugate. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1993, 1164, (2), 173-178.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Sicherheitshinweise: P261-P280-P305+P351+P338-P304+P340-P362-P301+P312-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,3717
Harmonized Tariff Code
2918.99
TSCA
No
RTECS
AG6600000

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