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51803-78-2 - Nimesulide - N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide - J63699 - Alfa Aesar

J63699 Nimesulide

CAS-Nummer
51803-78-2
Synonyme
N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide

Größe Preis ($) Menge Verfügbarkeit
5g 50,68
25g 178,20
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Nimesulide

MDL
MFCD00079470
EINECS
257-431-4

Chemische Eigenschaften

Formel
C13H12N2O5S
Molmasse
308.31
Form
Needle-like crystals
Schmelzpunkt
145-147°
Löslichkeit
Soluble in water (<50 &#181;g/ml), 1:10 DMSO:PBS (pH 7.2) (<200 &#181;g/ml), ethanol (1 mg/ml), DMSO (15 mg/ml), DMF (15 mg/ml), chloroform, dichloromethane, acetone (freely soluble), and 1N NaOH.

Anwendungen

Nimesulide are used for the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea, . Nimesulide was as effective as paracetamol in reducing fever, local pain, and general discomfort. It was effective in reducing pain associated with osteoarthritis, cancer, thrombophlebitis, oral surgery in adults, otorhinolaryngological diseases and traumatic injury. Nimesulide is demonstrated to suppress azoxymethane-induced carcinogenesis.

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Literaturverweise

Rick Davis,; Rex N. Brogden.Nimesulide, An Update of its Pharmacodynamic and Pharmacokinetic Properties, and Therapeutic Efficacy. Drugs. Drugs, 199448 (3), 431-454.

Alberto Bernaregg. Clinical Pharmacokinetics of Nimesulide. Clinical Pharmacokinetics. 1995, 35 (4), 247-274.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H301

Toxic if swallowed.

Sicherheitshinweise: P264-P270-P301+P310-P321-P330-P405-P501a

Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. Specific treatment (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,6548
Gefahrenklasse
6.1
Verpackungsgruppe
III
Harmonized Tariff Code
2935.00
TSCA
No
RTECS
PB0970000

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