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Dizocilpine maleate is used to interact at the NMDA-associated ion channel, preventing Ca2+ flux and blocking NMDA-induced depolarizations. (+)-MK 801 demonstrates potent neuroprotective effects against excitotoxic insult, showing substantial protection against neuron loss produced by NMDA and quinolinic acid introduction.
Lannes, B.; Bernard, V.; Bloch, B.; Micheletti, G. Chronic treatment with dizocilpine maleate increases the number of striatal neurons expressing the D2 receptor gene. Neuroscience. 1995, 65, (2), 431-438.
Salin, P.; Nieoullon, A.; Kerkerian-Le Goff, L. Reversal of the adaptive response of neuropeptide Y neurons in the rat striatum to nigrostriatal dopamine deafferentation by theN-methyl-d-aspartate antagonist dizocilpine maleate. Neuroscience. 1994, 61, (1), 93-105.