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J63927 Trypsin inhibitor, chicken egg whites

CAS-Nummer
9035-81-8
Synonyme
Trypsin inhibitor, ovomucoid

Stock No. Größe Preis ($) Menge Verfügbarkeit
J63927-ME 500mg 99,00
J63927-03 1g 170,00
J63927-04 2g 303,00
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Trypsin inhibitor, chicken egg whites

MDL
MFCD00082102
EINECS
232-906-9

Chemische Eigenschaften

Form
Powder
Storage & Sensitivity
Ambient temperatures.
Löslichkeit
Soluble in water (10 mg/ml), phosphate buffers (10 mg/ml), and balanced salt solutions (1 mg/ml).

Anwendungen

Soybean trypsin inhibior (STI) is a protein which reduces trypsin (a proteolytic enzyme) as well as plasma kallikrein, factor Xa and plasmin activity. Soybean trypsin inhibitor has demonstrated inhibition of human neutrophil elastase at an IC50=0.3 nM. At this concentration soybean trypsin inhibitor showed neither cytotoxic nor haemolytic effects on populations of human blood cells. In fibrin matrix, and without toxic effects, STI had a strong inhibitory effect on human umbilical vein endothelial cells migration and tubulogenesis.

Bemerkungen

One mg inhibits at least 1.2 mg of trypsin with activity of at least 180 units/mg, when a unit is defined as the amount of protein that hydrolyzes 1micromole of TAME per mite at 25°C, pH 8.2 in the presence of 0.1M calcium.

Literaturverweise

Robert Huber.; Dietmar Kukla.; Wolfram Bode.; Peter Schwager.; Klaus Bartels.; Johann Deisenhofe.; Wolfgang Steigemann. Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor : II. Crystallographic refinement at 1.9 Å resolution.J. Mol. Biol. 1974, 89 (1),73-101 .

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H334-H317

May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction.

Sicherheitshinweise: P284-P261-P280g-P342+P311a-P363-P501a

Wear respiratory protection. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves. If experiencing respiratory symptoms: Call a POISON CENTER/doctor. Wash contaminated clothing before reuse. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Harmonized Tariff Code
3504.00
TSCA
No

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